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徐嘉琳 Chia-Lin Hsu

 

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  Contact information:

   Chia-Lin Hsu

   Email: chialin.hsu@ym.edu.tw

   Phone number: +886-2-2826-7000 ext 5619

   Rm309, Traditional Medicine Building B, #155, Sec. 2, LiNong Street, National Yang-Ming University, Taipei, Taiwan

    web site:  http://www.ym.edu.tw/~chialin.hsu/index_e_CHsu%202015.html 

 

The philosophy of this lab: 

Doing research is not easy, but it is fun.  Being the first person to have a peek of Mother Nature’s design is just way too cool.  My goal is to provide an incubator for students who are interested in science to gain the first-hand experience of research life and thrive.  We welcome creative and curious minds to come join us. 

 

Education and Experiences:

2013- Current: Assistant Professor, Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan

2012-2013: Senior Scientist, Center of Therapeutic Innovation, Pfizer, San Francisco, California, U.S.A.

2007-2012: Postdoctoral Research Fellow, Department of Immunology, Genentech, South San Francisco, California, U.S.A. *Mentor: Dr. Flavius Martin

2002-2007: Ph.D., Department of Immunology, Duke University, Durham, North Carolina, U.S.A. *Mentor: Dr. Motonari Kondo

1999-2002: M.S. and Research assistant, Institute of Microbiology and Immunology, National Yang-Ming University; Department of Research and Teaching, Taipei General Veteran’s hospital, Taipei, Taiwan *Mentor: Dr. Cheng-Po Hu

1995-1999: B.S., Department of Zoology, National Taiwan University, Taipei, Taiwan

 

Research interest:

Immune response is one of the most delicate and complicated systems living organisms use to fend off environmental challenges.  This system can be divided into two major arms: innate and adaptive immunity.  Innate immunity is the first line of defense to remove insults as fast and efficiently as possible, and provides precious time for adaptive immunity to develop a “tailored” response to remove any residual pathogens.  The major theme of my lab is to understand the interplay between innate and adaptive immunity – how innate immune response is elicited and resolved, and how it affects adaptive immunity.  I am particularly interested in understanding how innate cells, such as dendritic cells and macrophages, sense intracellular pathogen signatures.  Great advances have been made recently in understanding the molecules involved in this process, however, questions such as how bacterial/viral DNA/RNA is released to cytosol remain largely unexplored.  Once the danger signals are confirmed, innate cells then initiate series of activating cascades that involve large amount of protein production and cell expansion for defense.  This rapid expansion of immune cells is a costly event for the body, and it is only economical if cellular building blocks/metabolites are recycled once the pathogen challenge is resolved.  What happens if this process is dysfunctional?  What kind of impact will it have on immune response?  Answers to these questions will not only provide insights to fundamental understanding of immune regulation, but also can be further applied to clinical needs such as vaccine design and therapeutics. 

 

Publications:

Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis. Hsu CL, Lin W, Seshasayee D, Chen YH, Ding X, Lin Z, Suto E, Huang Z, Lee WP, Park H, Xu M, Sun M, Rangell L, Lutman JL, Ulufatu S, Stefanich E, Chalouni C, Sagolla M, Diehl L, Fielder P, Dean B, Balazs M, Martin F.Science. 2012 Jan 6;335(6064):89-92.

Constitutive MAP kinase activation in hematopoietic stem cells induces a myeloproliferative disorder.Chung E, Hsu CL, Kondo M.PLoS One. 2011;6(12):e28350.

 To be or not to be: that is the question—Lineage Commitment in Hematopoiesis.  Hsu CL, Kondo M.Current Immunology Reviews, 2007 Nov:3 (4) pp. 258-268(11)

Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment. Hsu CL, Kikuchi K, Kondo M.

Blood. 2007 Sep 1;110(5):1420-8.

Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors. Hsu CL, King-Fleischman AG, Lai AY, Matsumoto Y, Weissman IL, Kondo M.Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):672-7.

IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF. Kikuchi K, Lai AY, Hsu CL, Kondo M.J Exp Med. 2005 Apr 18;201(8):1197-203.

The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. He YW, Li H, Zhang J, Hsu CL, Lin E, Zhang N, Guo J, Forbush KA, Bevan MJ.Nat Immunol. 2004 Jan;5(1):88-97.

 

Current Lab Members:

李定瑾 (Ding-Jin Lee), Master program, 2013-

蕭雯 (Wen Shiao), Master program, 2013-

 

 

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